Multi-spacecraft gradient techniques: Applicability for studying magnetosphere-ionosphere coupling J. De Keyser Belgian Institute for Space Aeronomy (invited talk) In this presentation we review different existing techniques for computing gradients from multi-spacecraft data, focussing in particular on least-squares gradient computation. A major question is: are such techniques useful in the context of the study of the coupling between the magnetosphere and the ionosphere in the auroral regions? We discuss the limitations of the methods and suggest where and how gradient computation is possible.